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InChiKey: ATXHVCQZZJYMCF-XUDSTZEESA-N
55)41(53)58-7
which correlates with effects on tumor growth
90 and IC50 of 126 pM
Chemical Name: 1-(2 (Diphenylmethoxy)ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
BSJ-03-123 rescein Diacetate InChiKey: ATXHVCQZZJYMCF-XUDSTZEESA-NBSJ 03 123 is a Selective Cdk6 degrader. BSJ 03 123 exploits protein interface determinants to achieve proteome wide selectivity for the degradation of cyclin dependent kinase 6 (CDK6). Pharmacologic CDK6 degradation targets a selective dependency of acute myeloid leukemia cells, and transcriptomics and phosphoproteomics profiling of acute degradation of CDK6 enabled dynamic mapping of its immediate role in coordinating signaling and transcription.
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